An expectation/maximization nuclear vector replacement algorithm for automated NMR resonance assignments
نویسندگان
چکیده
منابع مشابه
An expectation/maximization nuclear vector replacement algorithm for automated NMR resonance assignments.
We report an automated procedure for high-throughput NMR resonance assignment for a protein of known structure, or of an homologous structure. Our algorithm performs Nuclear Vector Replacement (NVR) by Expectation/Maximization (EM) to compute assignments. NVR correlates experimentally-measured NH residual dipolar couplings (RDCs) and chemical shifts to a given a priori whole-protein 3D structur...
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The overview of Autolink. The overview of Autolink is shown in Figure 1. The input data are spin systems obtained from CARA [2]. All possible spin system parings are considered and a “fitness” score is computed for each pair. A pair of spin systems and their fitness score form a “link hypothesis”. Each fitness score consists of several sub-scores representing specific resonance comparisons, suc...
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ژورنال
عنوان ژورنال: Journal of Biomolecular NMR
سال: 2004
ISSN: 0925-2738
DOI: 10.1023/b:jnmr.0000019247.89110.e6